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Plastimatch > Landmark-based Registartion

Before Registration
After Registration

General Information

Module Type & Category

Type: CLI

Category: Plastimatch

Authors, Collaborators & Contact

  • Authors: See COPYRIGHT.TXT contained within the package
  • Contact: Nadya Shusharina, Department of Radiation Oncology, Massachusetts General Hospital (
  • Web page:

Module Description

This is the plastimatch landmark-based deformable image registration module. The intended application of this method is rapid, interactive correction of registration failures with a small number of mouse clicks. Compared to other landmark-based methods, the plastimatch registration method might offer:

  1. both local and global registration
  2. regularization of the deformation field

Examples of how this module is being used:

  • Intra-subject registration for adaptive radiotherapy
  • Inter-subject registration for automatic segmentation



Quick Tour of Features and Use

  • Input/Output panel:
    • Fixed Volume: Here you choose the "fixed image", which is the reference image.
    • Moving Volume: Here you choose the "moving image", which will be warped to match the fixed image.
    • Output Volume: Here you choose where to put the warped image. You can replace an existing image in the scene, or create a new image.
    • Basis function: Here you can choose either tps (thin plate splines), or gauss (Gaussian RBF), or wendland (Wendland RBF).
    • RBF radius: Here you can choose the radius of RBF.
    • Number of clusters: Here you can choose the number of landmark clusters.
    • Stiffness: Here you can choose the regularization parameter.
    • Default Pixel Value: Here you can choose the value for pixels with unknown value.
User Interface


Notes from the Developer(s)

Developer-oriented documentation is found on the plastimatch web site:


This module has no dependencies.


Plastimatch features approximately 100 test cases.

Known bugs

Usability issues

Please report usability issues to the bug tracker.

Source code & documentation

We recommended to download the latest source code from subversion:


More Information

About plastimatch

Plastimatch is an open source software for deformable image registration. It is designed for high-performance volumetric registration of medical images, such as X-ray computed tomography (CT), magnetic resonance imaging (MRI), and positron emission tomography (PET). Software features include:

  • B-spline method for deformable image registration (GPU and multicore accelerated)
  • Demons method for deformable image registration (GPU accelerated)
  • ITK-based algorithms for translation, rigid, affine, demons, and B-spline registration
  • Pipelined, multi-stage registration framework with seamless conversion between most algorithms and transform types
  • Landmark-based deformable registration using thin-plate splines for global registration
  • Landmark-based deformable registration using radial basis functions for local corrections
  • Broad support for 3D image file formats (using ITK), including Dicom, Nifti, NRRD, MetaImage, and Analyze
  • Dicom and DicomRT import and export
  • XiO import and export
  • Plugins for 3D Slicer

Plastimatch also features two handy utilities which are not directly related to image registration:

  • FDK cone-beam CT reconstruction (GPU and multicore accelerated)
  • Digitally reconstructed radiograph (DRR) generation (GPU and multicore accelerated)


National Institutes of Health
NIH / NCI 6-PO1 CA 21239
Federal share of program income earned by MGH on C06CA059267

Progetto Rocca Foundation
A collaboration between MIT and Politecnico di Milano


  • G Sharp et al. "Plastimatch - An open source software suite for radiotherapy image processing," Proceedings of the XVIth International Conference on the use of Computers in Radiotherapy, May, 2010.
  • N. Shusharina, G. Sharp "Landmark-based image registration with analytic regularization", IEEE Trans. Med. Imag., submitted, 2011.