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Introduction and Acknowledgements

This work was supported by Comision Sectorial de Investigacion Cientıfica (CSIC, Universidad de la Republica, Uruguay) under program "Proyecto de Inclusión Social".
Author: Guillermo Carbajal, Álvaro Gómez, Universidad de la República, Uruguay
Contact: Guillermo Carbajal, <email></email>

Module Description

In refractory epilepsy, the goal of neuroimaging is to localize the region of seizure onset. Tracers that accumulate and remain fixed proportional to regional cerebral blood flow (rCBF) at the time of injection are used to obtain SPECT images of the brain activity during and between seizures. This module was developed to detect epileptogenic focus candidates using basal and ictal SPECT images. A MRI image can also be used. Below you will find how to detect epileptogenic focus candidates using this module.

Use Cases

Compare candidates obtained using SISCOM and a-contrario method.

Epileptogenic focus candidates



Panels and their use

  • Load Studies: The following studies are required:
    • SPECT basal
    • SPECT ictal
    • MRI (optional: for visualization of the results or SPECT/MRI registration)
  • Registration: To compare the basal SPECT and the icatl SPECT the volumes must be registered. In this step it is possible to perform:
    • SPECT basal/SPECT ictal registration
    • SPECT/MRI registration (if MRI Available)
    • SPECT basal/SPECT ictal mask (intersection) computation
  • Foci detection: Differential (SISCOM) and a-contrario methods are implemented. Results can be visualized in MRI Space (if available) or SPECT Space. Results can be compared.
    • Differential method: The most used technique for detecting the epileptogenic zone(EZ) is to threshold the co-registered and normalized subtraction of these two images. This method has proven to be very useful but has the disadvantage that the result depends on the selected threshold.
    • A-contrario: to be described

Similar Modules



Aguerrebere C, Sprechmann P, Musé P, Ferrando R. A-contrario localization of epileptogenic zones in SPECT images. IEEE International Symposium on Biomedical Imaging: From Nano to Macro, 2009. ISBI '09
Ferrando R, Aguerrebere C, Albin G, Fernández A, Gómez A, Miceli F, Mottini A, Musé P, Nuñez M, Sprechmann P. Localization of epiloptogenic zones in SPECT images using an A-Contrario based algorithm. Evaluation with virtual phantoms and patients. Journal of Nuclear Medicine. 2010;51(suppl):494
Mottini A, Miceli F, Albin G, Nuñez M, Ferrando R, Aguerrebere C, Fernández A. Integrated software for the detection of epileptogenic zones in refractory epilepsy. Conf Proc IEEE Eng Med Biol Soc. 2010;2010:5700-3

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