Slicer3:UIDesign:WorkingProblems:BCAnalysis:PET

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Back to Project Overview

SUV Analysis for Breast Cancer

Goal

Goal is to accommodate basic RECIST assessment for breast cancer (Response Evaluation Criteria In Solid Tumors). (RECIST is a set of published rules that define when cancer patients improve ("respond"), stay the same ("stable") or worsen ("progression") during treatments).

  • Determine features that currently exist in Slicer
  • Develop features that don't
  • Provide a framework that knits features together in a comfortable workflow.

PET SUV Analysis Workflow

  • Segment the tumor by hand (ROI or VOI, can be simple circle or ellipsoid)
  • Compute SUV of baseline
    • extract parameters from dicom header including
      • concentration
      • injected activity
      • patient weight
    • SUV = ( concentration (microcuries/cc) / injected activity (microcuries) ) - (patient weight (g))
    • use maximum value
  • Compute SUV of followup
    • extract parameters from dicom header including
      • concentration
      • injected activity
      • patient weight
    • SUV = ( concentration (microcuries/cc) / injected activity (microcuries) ) - (patient weight (g))
    • use maximum value
  • Normalize ROI by SUVmax
  • Resport parameters of interest
    • SUVmax_baseline,
    • SUVmax_followup,
    •  % change
  • For multiple tumors, report
    • sum of SUV_baselines
    • sum of SUV_followup
    • percent change

Approach

Started a PET_SUV module in Slicer that

  • lets you choose a pre-treatment pet volume
  • lets you choose a post-treatment CT volume (if present)
  • lets you choose pre & post-treatment label maps.
  • displays them in FG/BG with correct LUT
  • pulls parameters of interest for SUV calculation from DICOM header
  • has entry widget for parameters missing from header
  • computes measures of interest as described above.
  • no special viewer for now.
  • ...

Resources

Display guide

case study MS PPT Slides shows tumor

MS Word document with DICOM tags for SUV

Slicer Display at present

Initial view in Slicer (w/o volume rendering)

PPT files

Slides for Volumetric Analysis (in progress)