Difference between revisions of "Slicer3:UIDesign:WorkingProblems:BCAnalysis:PET"

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* Same case as Draft display -- same case as ppt slides?
 
* Same case as Draft display -- same case as ppt slides?
 
* Check DICOM tags; not all are found for computing suv?
 
* Check DICOM tags; not all are found for computing suv?
 +
** Radiopharmaceutical Start Time 0018,1072
 +
** Decay Correction 0054,1102
 +
** Decay Factor 0054,1321
 +
** Frame Reference Time 0054,1300
 +
** Radionuclide Half Life 0018,1075
 +
** Series Time 0008,0032
 +
** Patient Weight 0010,1030
 +
** Radionuclide Total Dose 0018,1074
 +
** Correction 7053,1009 (counts to Bq/cc)
 +
** Philips SUV Factor 7053,1000 (custom)
 
* Normalize ROI by SUVmax?  
 
* Normalize ROI by SUVmax?  
 
* Get good volume render for slides.
 
* Get good volume render for slides.

Revision as of 10:48, 14 September 2009

Home < Slicer3:UIDesign:WorkingProblems:BCAnalysis:PET

Back to Project Overview

SUV Analysis for Breast Cancer

Goal

Goal is to accommodate basic RECIST assessment for breast cancer (Response Evaluation Criteria In Solid Tumors). (RECIST is a set of published rules that define when cancer patients improve ("respond"), stay the same ("stable") or worsen ("progression") during treatments).

  • Determine features that currently exist in Slicer
  • Develop features that don't
  • Provide a framework that knits features together in a comfortable workflow.

PET SUV Analysis Workflow

  • Segment the tumor by hand (ROI or VOI, can be simple circle or ellipsoid)
  • Compute SUV of baseline
    • extract parameters from dicom header including
      • concentration
      • injected activity
      • patient weight
    • SUV = ( concentration (microcuries/cc) / injected activity (microcuries) ) - (patient weight (g))
    • use maximum value
  • Compute SUV of followup
    • extract parameters from dicom header including
      • concentration
      • injected activity
      • patient weight
    • SUV = ( concentration (microcuries/cc) / injected activity (microcuries) ) - (patient weight (g))
    • use maximum value
  • Normalize ROI by SUVmax
  • Resport parameters of interest
    • SUVmax_baseline,
    • SUVmax_followup,
    •  % change
  • For multiple tumors, report
    • sum of SUV_baselines
    • sum of SUV_followup
    • percent change

Approach

Started a PET_SUV module in Slicer that

  • lets you choose a pre-treatment pet volume
  • lets you choose a post-treatment CT volume (if present)
  • lets you choose pre & post-treatment label maps.
  • displays them in FG/BG with correct LUT
  • pulls parameters of interest for SUV calculation from DICOM header
  • has entry widget for parameters missing from header
  • computes measures of interest as described above.
  • no special viewer for now.
  • ...

Resources

Display guide

case study MS PPT Slides shows tumor

MS Word document with DICOM tags for SUV

Slicer Display at present

Initial view in Slicer (w/o volume rendering)
Ron's PETCT in Slicer: GPU Raycasting (GLSL) with Gradient Magnitude Opacity Modulation
Draft module (w/o display) DICOM Tags missing?

TODO & Questions for Ron/Jeffrey

  • Same case as Draft display -- same case as ppt slides?
  • Check DICOM tags; not all are found for computing suv?
    • Radiopharmaceutical Start Time 0018,1072
    • Decay Correction 0054,1102
    • Decay Factor 0054,1321
    • Frame Reference Time 0054,1300
    • Radionuclide Half Life 0018,1075
    • Series Time 0008,0032
    • Patient Weight 0010,1030
    • Radionuclide Total Dose 0018,1074
    • Correction 7053,1009 (counts to Bq/cc)
    • Philips SUV Factor 7053,1000 (custom)
  • Normalize ROI by SUVmax?
  • Get good volume render for slides.
  • Help from Nicole on min/max & LUT scaling -- access via volumes module (not exposed in API)?
  • PropagateVolumeSelection after touching node selectors auto-fits data to win -- so annoying! fix.

PPT files

Slides for Volumetric Analysis (in progress)