Difference between revisions of "Main Page/SlicerCommunity/2020"

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Tag: 2017 source edit
Tag: 2017 source edit
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=2020=
 
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==Visualization of Mucosal Field in HPV Positive and Negative Oropharyngeal Squamous Cell Carcinomas: Combined Genomic and Radiology Based 3D Model==
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'''Publication:''' [https://www.ncbi.nlm.nih.gov/pubmed/31913295 Sci Rep. 2020 Jan 8;10(1):40. PMID: 31913295] | [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6949264/pdf/41598_2019_Article_56429.pdf  PDF]
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'''Authors:''' Orosz E, Gombos K, Petrevszky N, Csonka D, Haber I, Kaszas B, Toth A, Molnar K, Kalacs K, Piski Z, Gerlinger I, Burian A, Bellyei S, Szanyi I.
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'''Institution:'''
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University of Pécs, Medical School, Department of Otorhinolaryngology, Pécs, Hungary.
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'''Abstract:''' The aim of this study was to visualize the tumor propagation and surrounding mucosal field in radiography-based 3D model for advanced stage HNSCC and combine it with HPV genotyping and miRNA expression characterization of the visualized area. 25 patients with T1-3 clinical stage HNSCC were enrolled in mapping biopsy sampling. Biopsy samples were evaluated for HPV positivity and miR-21-5p, miR-143, miR-155, miR-221-5p expression in Digital Droplet PCR system. Significant miRNA expression differences of HPV positive tumor tissue biopsies were found for miR-21-5p, miR-143 and miR-221-5p compared to the HPV negative tumor biopsy series. Peritumoral mucosa showed patchy pattern alterations of miR-21-5p and miR-155 in HPV positive cases, while gradual change of miR-21-5p and miR-221-5p was seen in HPV negative tumors. In our study we found differences of the miRNA expression patterns among the HPV positive and negative tumorous tissues as well as the surrounding mucosal fields. The CT based 3D models of the cancer field and surrounding mucosal surface can be utilized to improve proper preoperative planning. Complex evaluation of HNSCC tissue organization field can elucidate the clinical and molecular differentiation of HPV positive and negative cases, and enhance effective organ saving therapeutic strategies.
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| align="right" |[[image:Orosz-Sci Rep2020-fig5.jpeg|thumb|300px|HR CT image and 3D model of a HPV negative stage T3 tonsillar squamous cell carcinoma. Tumor mass is marked red on the horizontal, sagittal and frontal planes in all sections and a 3D model is built up based on the CT segments on the upper right quarter of the picture. ]]]
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Revision as of 15:16, 10 February 2020

Home < Main Page < SlicerCommunity < 2020

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The community that relies on 3D Slicer is large and active: (numbers below updated on December 1st, 2023)

  • 2,147+ papers on PubMed citing the Slicer platform paper
    • Fedorov A., Beichel R., Kalpathy-Cramer J., Finet J., Fillion-Robin J-C., Pujol S., Bauer C., Jennings D., Fennessy F.M., Sonka M., Buatti J., Aylward S.R., Miller J.V., Pieper S., Kikinis R. 3D Slicer as an Image Computing Platform for the Quantitative Imaging Network. Magnetic Resonance Imaging. 2012 Nov;30(9):1323-41. PMID: 22770690. PMCID: PMC3466397.


The following is a sample of the research performed using 3D Slicer outside of the group that develops it. in 2020

We monitor PubMed and related databases to update these lists, but if you know of other research related to the Slicer community that should be included here please email: marianna (at) bwh.harvard.edu.

2020

Visualization of Mucosal Field in HPV Positive and Negative Oropharyngeal Squamous Cell Carcinomas: Combined Genomic and Radiology Based 3D Model

Publication: Sci Rep. 2020 Jan 8;10(1):40. PMID: 31913295 | PDF

Authors: Orosz E, Gombos K, Petrevszky N, Csonka D, Haber I, Kaszas B, Toth A, Molnar K, Kalacs K, Piski Z, Gerlinger I, Burian A, Bellyei S, Szanyi I.

Institution: University of Pécs, Medical School, Department of Otorhinolaryngology, Pécs, Hungary.

Abstract: The aim of this study was to visualize the tumor propagation and surrounding mucosal field in radiography-based 3D model for advanced stage HNSCC and combine it with HPV genotyping and miRNA expression characterization of the visualized area. 25 patients with T1-3 clinical stage HNSCC were enrolled in mapping biopsy sampling. Biopsy samples were evaluated for HPV positivity and miR-21-5p, miR-143, miR-155, miR-221-5p expression in Digital Droplet PCR system. Significant miRNA expression differences of HPV positive tumor tissue biopsies were found for miR-21-5p, miR-143 and miR-221-5p compared to the HPV negative tumor biopsy series. Peritumoral mucosa showed patchy pattern alterations of miR-21-5p and miR-155 in HPV positive cases, while gradual change of miR-21-5p and miR-221-5p was seen in HPV negative tumors. In our study we found differences of the miRNA expression patterns among the HPV positive and negative tumorous tissues as well as the surrounding mucosal fields. The CT based 3D models of the cancer field and surrounding mucosal surface can be utilized to improve proper preoperative planning. Complex evaluation of HNSCC tissue organization field can elucidate the clinical and molecular differentiation of HPV positive and negative cases, and enhance effective organ saving therapeutic strategies.

File:Orosz-Sci Rep2020-fig5.jpeg
HR CT image and 3D model of a HPV negative stage T3 tonsillar squamous cell carcinoma. Tumor mass is marked red on the horizontal, sagittal and frontal planes in all sections and a 3D model is built up based on the CT segments on the upper right quarter of the picture.
]