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Home < Documentation < Nightly < Modules < DistanceMapBasedRegistration

For the stable Slicer documentation, visit the 4.10 page.

Introduction and Acknowledgements

Acknowledgments: This work is/was supported in part the National Institutes of Health, National Cancer Institute through the following grants:

Authors: Andrey Fedorov (SPL), Andras Lasso (Queen's University)
Contact: Andrey Fedorov, <email></email>

License: Slicer License

National Center for Image Guided Therapy (NCIGT)  
Quantitative Image Informatics for Cancer Research  
Surgical Planning Laboratory (SPL)  

Module Description

This module was originally developed to enable registration between segmented MRI and transrectal ultrasound (TRUS) images of the prostate. The registration approach is based on hierarchical deformable registration of the smoothed distance maps of the segmentation masks (see details in the publication provided in the references section), and thus is not modality- or organ-specific, and can be applied in other applications.
Example visualization of MRI/TRUS registration result obtained using this module. Yellow outline is the contour of the manual segmentation of the prostate gland in TRUS, over the registered MRI image of the same prostate.

Use Cases

  • MRI-ultrasound fusion biopsy of the prostate (primary)
  • therapy planning
  • treatment response assessment


None at this time ... stay tuned!

Panels and their use

See module description

Similar Modules

Add registration modules here


[1] Fedorov A, Khallaghi S, Antonio Sánchez C, Lasso A, Fels S, Tuncali K, Neubauer Sugar E, Kapur T, Zhang C, Wells W, Nguyen PL, Abolmaesumi P, Tempany C. (2015) Open-source image registration for MRI–TRUS fusion-guided prostate interventions. Int J CARS: 1–10. Available:

[2] Fedorov A, Nguyen PL, Tuncali K, Tempany C. (2015). Annotated MRI and ultrasound volume images of the prostate. Zenodo.

Information for Developers