Difference between revisions of "Documentation/4.2/Extensions/PkModeling"

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{{documentation/{{documentation/version}}/module-section|Introduction and Acknowledgements}}
 
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Extension: [[Documentation/{{documentation/version}}/Extensions/PkModeling|PkModeling]]<br>
 
Acknowledgments:
 
This work is part of the National Alliance for Medical Image Computing (NA-MIC), funded by the National Institutes of Health through the NIH Roadmap for Medical Research.<br>
 
Implementation of the pharmacokinetics modeling was contributed by Yingxuan Zhu and Jim Miller from GE Research.<br>
 
Author: Yingxuan Zhu, Jim Miller ({{collaborator|name|ge}})<br>
 
Contact: Yingxuan Zhu, <email>zhuyi@ge.com</email><br>
 
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PkModeling (Pharmacokinetics Modeling) calculates quantitative parameters from Dynamic Contrast Enhanced DCE-MRI images. This module performs two operations:
 
# Converts signal intensities to concentration values. The concentration values are used to calculate quantitative parameters.
 
# Calculates quantitative parameters from concentration values. These parameters include:
 
;Ktrans: Volume transfer constant between blood plasma and EES (extracellular-extravascular space) at each voxel
 
;Ve: Fractional volume for extracellular space at each voxel
 
;MaxSlope: Maximum slope in the time series curve of each voxel
 
;AUC: Area under the curve of each voxel, measured from bolus arrival time to the end time of interval, normalized by the AUC of the AIF
 
 
 
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* '''IO'''
 
** '''Input:''' 4D DCE-MRI data; 3D mask showing the location of the arterial input function.
 
** '''Output:''' 4 volumes showing the maps of quantitative parameters: ktrans, ve, maximum slope, and area under the curve (AUC).
 
* '''Parameters'''
 
** '''PkModeling''':
 
*** T1 Blood Value
 
*** T1 Tissue Value
 
*** Relaxivity Value
 
*** Hematocrit Value. Volume percentage of red blood cells in blood.
 
*** AUC Time Interval Value: Time interval for AUC calculation
 
** '''Acquisition''':
 
*** TR Value: Repetition time,
 
*** TE Value: Echo time,
 
*** FA Value: Flip angle,
 
*** Time Axis: Time series.
 
 
 
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{{documentation/{{documentation/version}}/module-section|Similar Modules}}
 
* [[Documentation/{{documentation/version}}/Modules/MultiVolumeExplorer|MultiVolumeExplorer]]
 
* [[Documentation/{{documentation/version}}/Modules/MultiVolumeImporter|MultiVolumeImporter]]
 
 
 
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* Knopp MV, Giesel FL, Marcos H et al: Dynamic contrast-enhanced magnetic resonance imaging in oncology. Top Magn Reson Imaging, 2001; 12:301-308.
 
* Rijpkema M, Kaanders JHAM, Joosten FBM et al: Method for quantitative mapping of dynamic MRI contrast agent uptake in human tumors. J Magn Reson Imaging 2001; 14:457-463.
 
 
 
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[[Category:Documentation/{{documentation/version}}/Modules/Quantification]]
 
 
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Latest revision as of 15:43, 25 July 2013

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