Documentation/4.0/Modules/N4ITKBiasFieldCorrection

Introduction and Acknowledgements

• This work is part of the National Alliance for Medical Image Computing (NA-MIC), funded by the National Institutes of Health through the NIH Roadmap for Medical Research, Grant U54 EB005149. Information on NA-MIC can be obtained from the NA-MIC website. The development of this module was supported in part by NIH grants R01 AA016748-01, R01 CA111288 .... check grants.
• Authors: Nick Tustison (N4ITK filters), Ron Kikinis (PI + design and inspiration), Andrey Fedorov (design, ITK filter modifications, 3D Slicer module)
• Contact: Andrey Fedorov, <email>fedorov@bwh.harvard.edu</email>

Template:Documentation/4.0/module-introduction-logoTemplate:Documentation/4.0/module-introduction-logo

Use Cases

This module is especially appropriate for these use cases:

• Image acquisition is done with a surface coil, and you observe signal fall-off as you get further away from the coil (this is particularly the case at higher field strengths)
• You observe smooth variation of the intensity over the tissue that should have intensity close to uniform
• Your attempts to segment or register your data are not successful, and you are not sure what to do next

Examples of the module in use:

• Correction of the signal inhomogeneity in prostate MRI obtained with endorectal coil at 3T field strength

Prostate erMRI

After bias correction

Before - After subtract image

Recovered bias field

• Correction of the bias in vervet MRI. Acquisition parameters: 3T GE scanner, single-channel dedicated RF coil (Litzcage, Doty Scientific, Columbia, SC); 3D SPGR sequence (TI 600ms, TE 3.276ms, TR 15.28ms; flip angle 15 deg; matrix 256x256; FOV 12cm; in-plane resolution 0.47 mm; slice thickness 0.5 mm).

Slice of the input test volume with apparent bias field and label outlines

Output image visually contains less inhomogeneity

Before - After subtract image

Recovered bias field

Tutorials

Links to tutorials that use this module

Panels

• Point to other modules that have similar functionality

References

Publications related to this module go here. Links to pdfs would be useful. For extensions: link to the source code repository and additional documentation