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| − | A progressive post-onset decrease in gray matter volume 1.5 years after first hospitalization in
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| − | schizophrenia has been shown in superior temporal gyrus (STG). However, it is still controversial
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| − | whether progressive volume reduction occurs in chronic schizophrenia in the STG and amygdala–
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| − | hippocampal complex (AHC), structures found to be abnormal in chronic schizophrenia. These
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| − | structureswere measured at two time points in 16 chronic schizophrenia patients and 20 normal
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| − | comparison subjects using manual tracing with high spatial resolution magnetic resonance
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| − | imaging(MRI).Average interscan intervalwas 3.1 years for schizophrenia patients and 1.4 years for
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| − | healthy comparison subjects.
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| − | Cross-sectional comparisons showed smaller relative volumes in schizophrenia compared with
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| − | controls in posterior STG and AHC. An ANCOVA with interscan interval as a covariate showed
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| − | there was no statistically significant progression of volume reduction in either the STG or AHC
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| − | in the schizophrenia group compared with normal subjects. In the schizophrenia group, volume
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| − | change in the left anterior AHC significantly correlated with PANSS negative symptoms.
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| − | These data, and separately reported first episode data from our laboratory, suggest marked
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| − | progression at the initial stage of schizophrenia, but less in chronic schizophrenia.
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