Documentation/4.1/Modules/PkModeling - Revision history

UpdateBot: Prepend documentation/versioncheck template. See http://na-mic.org/Mantis/view.php?id=2887

2013-06-14T07:28:58Z

Prepend documentation/versioncheck template. See http://na-mic.org/Mantis/view.php?id=2887

2012-06-26T22:19:13Z

2012-06-19T15:39:55Z

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2012-06-14T20:13:19Z

2012-06-14T20:13:01Z

2012-06-14T20:11:00Z

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2012-06-14T20:08:58Z

2012-06-14T20:08:25Z

← Older revision		Revision as of 07:28, 14 June 2013
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	{{documentation/{{documentation/version}}/module-header}}		{{documentation/{{documentation/version}}/module-header}}

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 {{documentation/{{documentation/version}}/module-section|Similar Modules}}
-* [[Documentation/4.1/Modules/MultiVolumeExplorer]]
+* [[Documentation/{{documentation/version}}/Modules/MultiVolumeExplorer|MultiVolumeExplorer]]
-* [[Documentation/4.1/Modules/MultiVolumeImporter]]
+* [[Documentation/{{documentation/version}}/Modules/MultiVolumeImporter|MultiVolumeImporter]]
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 {|
-|[[Image:PkModelingUI061212.png|thumb|340px|PkModeling]]
+|[[Image:PkModelingUI061912.png|thumb|340px|PkModeling]]
+|
 * '''IO'''

@@ Line 57: / Line 57: @@
 *** T1 Tissue Value
 *** Relaxivity Value
-*** Hematocrit Value
+*** Hematocrit Value. Volume percentage of red blood cells in blood.
 *** AUC Time Interval Value: Time interval for AUC calculation
 ** '''Acquisition''':

@@ Line 9: / Line 9: @@
 Extension: [[Documentation/{{documentation/version}}/Extensions/PkModeling|PkModeling]]<br>
 Acknowledgments:
-This work is part of the National Alliance for Medical Image Computing (NAMIC), funded by the National Institutes of Health through the NIH Roadmap for Medical Research.<br>
+This work is part of the National Alliance for Medical Image Computing (NA-MIC), funded by the National Institutes of Health through the NIH Roadmap for Medical Research.<br>
 Implementation of the pharmacokinetics modeling was contributed by Yingxuan Zhu and Jim Miller from GE Research.<br>
 Author: Yingxuan Zhu, Jim Miller ({{collaborator|name|ge}})<br>

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 {|
+|
-PkModeling (Pharmacokinetics Modeling) is to calculate the quantitative parameters from DCE-MRI images. The two major parts of it are:
+PkModeling (Pharmacokinetics Modeling) calculates quantitative parameters from Dynamic Contrast Enhanced DCE-MRI images. This module performs two operations:
-# Convert signal intensities to concentration values. The concentration values will be used to calculate quantitative parameters.
+# Converts signal intensities to concentration values. The concentration values are used to calculate quantitative parameters.
-# Calculate quantitative parameters from concentration values. These parameters include:
+# Calculates quantitative parameters from concentration values. These parameters include:
 ;Ktrans: Volume transfer constant between blood plasma and EES (extracellular-extravascular space) at each voxel
 ;Ve: Fractional volume for extracellular space at each voxel

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 * '''Parameters'''
 ** '''PkModeling''':
-**** T1 Blood Value
+*** T1 Blood Value
-**** T1 Tissue Value
+*** T1 Tissue Value
-**** Relaxivity Value
+*** Relaxivity Value
-**** Hematocrit Value
+*** Hematocrit Value
-**** AUC Time Interval Value: Time interval for AUC calculation
+*** AUC Time Interval Value: Time interval for AUC calculation
 ** '''Acquisition''':
 *** TR Value: Repetition time,

@@ Line 50: / Line 50: @@
+|
 * '''IO'''
-** '''Input:''' 4D DCE-MRI data in nrrd; 3D mask in nrrd, showing the location of arterial input function.
+** '''Input:''' 4D DCE-MRI data; 3D mask showing the location of the arterial input function.
-** '''Output:''' 4 volumes in nrrd, showing the maps of quantitative parameters. These parameters are ktrans, ve, maximum slope, and area under the curve (AUC).
+** '''Output:''' 4 volumes showing the maps of quantitative parameters: ktrans, ve, maximum slope, and area under the curve (AUC).
 * '''Parameters'''
 ** '''PkModeling''':

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 # Convert signal intensities to concentration values. The concentration values will be used to calculate quantitative parameters.
 # Calculate quantitative parameters from concentration values. These parameters include:
-;Ktrans: volume transfer constant between blood plasma and EES (extracellular-extravascular space) at each voxel
+;Ktrans: Volume transfer constant between blood plasma and EES (extracellular-extravascular space) at each voxel
-;Ve: fractional volume for extracellular space at each voxel
+;Ve: Fractional volume for extracellular space at each voxel
-;MaxSlope: maximum slope in the time series curve of each voxel
+;MaxSlope: Maximum slope in the time series curve of each voxel
-;AUC: area under the curve of each voxel, measured from bolus arrival time to the end time of interval, normalized by the AUC of the AIF
+;AUC: Area under the curve of each voxel, measured from bolus arrival time to the end time of interval, normalized by the AUC of the AIF
 |}