https://www.slicer.org/w/api.php?action=feedcontributions&feedformat=atom&user=TakeshiYoshida 2026-04-21T13:47:46Z User contributions MediaWiki 1.33.0 https://www.slicer.org/w/index.php?title=Talk:Main_Page&diff=10734 2009-09-24T04:56:51Z

<p>TakeshiYoshida: Created page with 'A progressive post-onset decrease in gray matter volume 1.5 years after first hospitalization in schizophrenia has been shown in superior temporal gyrus (STG). However, it is sti…'</p> <hr /> <div>A progressive post-onset decrease in gray matter volume 1.5 years after first hospitalization in<br /> schizophrenia has been shown in superior temporal gyrus (STG). However, it is still controversial<br /> whether progressive volume reduction occurs in chronic schizophrenia in the STG and amygdala–<br /> hippocampal complex (AHC), structures found to be abnormal in chronic schizophrenia. These<br /> structureswere measured at two time points in 16 chronic schizophrenia patients and 20 normal<br /> comparison subjects using manual tracing with high spatial resolution magnetic resonance<br /> imaging(MRI).Average interscan intervalwas 3.1 years for schizophrenia patients and 1.4 years for<br /> healthy comparison subjects.<br /> Cross-sectional comparisons showed smaller relative volumes in schizophrenia compared with<br /> controls in posterior STG and AHC. An ANCOVA with interscan interval as a covariate showed<br /> there was no statistically significant progression of volume reduction in either the STG or AHC<br /> in the schizophrenia group compared with normal subjects. In the schizophrenia group, volume<br /> change in the left anterior AHC significantly correlated with PANSS negative symptoms.<br /> These data, and separately reported first episode data from our laboratory, suggest marked<br /> progression at the initial stage of schizophrenia, but less in chronic schizophrenia.</div>

TakeshiYoshida