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A Review of Diffusion Tensor Imaging Studies in Schizophrenia
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Kubicki M., McCarley R.W., Westin C-F., Park H-J., Maier S.E., Kikinis R., Jolesz F.A., Shenton M.E.
Institution: |
Clinical Neuroscience Division, Laboratory of Neuroscience, Boston VA Health Care System-Brockton Division, Department of Psychiatry, Harvard Medical School |
Publisher: |
Elsevier Science |
Publication Date: |
Jan-2007 |
Volume Number: |
41 |
Issue Number: |
1-2 |
Pages: |
15-30 |
Citation: |
J Psychiatr Res. 2007 Jan-Feb;41(1-2):15-30. |
PubMed ID: |
16023676 |
PMCID: |
PMC2768134 |
Keywords: |
Diffusion Tensor Imaging, Schizophrenia, White matter, Fiber tracts, Projects:DTIStochasticTractographyClinical |
Appears in Collections: |
PNL, LMI, MIPG, NAC, NCIGT, SLICER, SPL |
Sponsors: |
NIH R03 MH068464-01 NIH K02 MH01110 NIH R01 MH50747 NIH R01 NS39335 NIH R01 MH40799 NIH P41 RR13218 Post-doctoral Fellowship Program of Korea Science and Engineering Foundation (KOSEF) Department of Veterans Affairs Merit Awards |
Generated Citation: |
Kubicki M., McCarley R.W., Westin C-F., Park H-J., Maier S.E., Kikinis R., Jolesz F.A., Shenton M.E. A Review of Diffusion Tensor Imaging Studies in Schizophrenia. J Psychiatr Res. 2007 Jan-Feb;41(1-2):15-30. PMID: 16023676. PMCID: PMC2768134. |
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Both post-mortem and neuroimaging studies have contributed significantly to what we know about the brain and schizophrenia. MRI studies of volumetric reduction in several brain regions in schizophrenia have confirmed early speculations that the brain is disordered in schizophrenia. There is also a growing body of evidence suggesting that a disturbance in connectivity between different brain regions, rather than abnormalities within the separate regions themselves, are responsible for the clinical symptoms and cognitive dysfunctions observed in this disorder. Thus an interest in white matter fiber tracts, subserving anatomical connections between distant, as well as proximal, brain regions, is emerging. This interest coincides with the recent advent of diffusion tensor imaging (DTI), which makes it possible to evaluate the organization and coherence of white matter fiber tracts. This is an important advance as conventional MRI techniques are insensitive to fiber tract direction and organization, and have not consistently demonstrated white matter abnormalities. DTI may, therefore, provide important new information about neural circuitry, and it is increasingly being used in neuroimaging studies of psychopathological disorders. Of note, in the past five years 18 DTI studies in schizophrenia have been published, most describing white matter abnormalities. Questions still remain, however, regarding what we are measuring that is abnormal in this disease, and how measures obtained using one method correspond to those obtained using other methods? Below we review the basic principles involved in MR-DTI, followed by a review of the different methods used to evaluate diffusion. Finally, we review MR-DTI findings in schizophrenia.
Additional Material
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