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A Method for Clustering White Matter Fiber Tracts
Institution:
 MIT Computer Science and AI Lab, Cambridge, MA 02139, USA.
Publisher:
 AJNR Am J Neuroradiol
Publication Date:
 May-2006
Volume Number:
 27
Issue Number:
 5
Pages:
 1032-1036
Citation:
 AJNR Am J Neuroradiol. 2006 May;27(5):1032-6.
PubMed ID:
 16687538
PMCID:
 PMC2768142
Keywords:
 DTI Clustering, Corpus, white matter fiber tracts, Projects:DTIClustering, Projects:DTIStochasticTractographyClinical
Appears in Collections:
SPL, LMI, NA-MIC, NAC, PNL, SLICER
Sponsors:
 NINDS 1-R01-NS051826-01
NIMH K02 MH 01110
NCRR P41 RR13218
NIMH R03 MH 068464-02
NIBIB U54 EB005149
Generated Citation:
 O'Donnell L., Kubicki M., Shenton M.E., Dreusicke M.H., Grimson W.E.L., Westin C-F. A Method for Clustering White Matter Fiber Tracts. AJNR Am J Neuroradiol. 2006 May;27(5):1032-6. PMID: 16687538. PMCID: PMC2768142.
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Despite its potential for visualizing white matter fiber tracts in vivo, diffusion tensor tractography has found only limited applications in clinical research in which specific anatomic connections between distant regions need to be evaluated. We introduce a robust method for fiber clustering that guides the separation of anatomically distinct fiber tracts and enables further estimation of anatomic connectivity between distant brain regions. METHODS: Line scanning diffusion tensor images (LSDTI) were acquired on a 1.5T magnet. Regions of interest for several anatomically distinct fiber tracts were manually drawn; then, white matter tractography was performed by using the Runge-Kutta method to interpolate paths (fiber traces) following the major directions of diffusion, in which traces were seeded only within the defined regions of interest. Next, a fully automatic procedure was applied to fiber traces, grouping them according to a pairwise similarity function that takes into account the shapes of the fibers and their spatial locations. RESULTS: We demonstrated the ability of the clustering algorithm to separate several fiber tracts which are otherwise difficult to define (left and right fornix, uncinate fasciculus and inferior occipitofrontal fasciculus, and corpus callosum fibers). CONCLUSION: This method successfully delineates fiber tracts that can be further analyzed for clinical research purposes. Hypotheses regarding specific fiber connections and their abnormalities in various neuropsychiatric disorders can now be tested.

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