The Publication Database hosted by SPL

All Publications | Upload | Advanced Search | Gallery View | Download Statistics | Help | Import | Log in

Measurement of Cortical Thickness in 3D Brain MRI Data: Validation of the Laplacian Method
Institution:
 Department of Neurology, Children's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA.
Publisher:
 J Neuroimaging
Publication Date:
 Apr-2006
Volume Number:
 16
Issue Number:
 2
Citation:
 J Neuroimaging. 2006 Apr;16(2):146-53.
PubMed ID:
 16629737
Keywords:
 Brain, cortex, Laplace, MRI, thickness
Appears in Collections:
SPL, SLICER
Sponsors:
 NINDS P01 NS 38475
Generated Citation:
 Haidar H., Soul J.S. Measurement of Cortical Thickness in 3D Brain MRI Data: Validation of the Laplacian Method. J Neuroimaging. 2006 Apr;16(2):146-53. PMID: 16629737.
Downloaded: 1186 times. [view map]
Paper: Download, View online
Export citation:

We aimed to determine the precision of the Laplacian approach for cortical thickness measurement due to changes in computational and acquisition parameters. We compared these results to two other methods widely used in clinical research using brain MRI data. MATERIALS AND METHODS: Brain MRI scans were obtained in 10 healthy adults using three different sets of acquisition parameters. The first and the second acquisitions used different slice thickness but the same head position. The third scan was performed after head repositioning. We measured cerebral cortical thickness in all brain segmentations using three thickness methods: Laplacian, nearest distance, and the orthogonal projection. RESULTS: The Laplacian method demonstrated the least variability with regard to the effect of interchange of boundaries, slice thickness, and repositioning of the head, compared with the other two methods. CONCLUSION: The Laplacian method is the most precise and reliable tool for in vivo cortical thickness measurement using brain MRI data.

Additional Material
1 File (240.642kB)
Haidar-JON2006-fig1.jpg (240.642kB)