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3D Histological Reconstruction of Fiber Tracts and Direct Comparison with Diffusion Tensor MRI Tractography
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Institution: |
Computational Radiology Laboratory, Children’s Hospital, Brigham and Women’s Hospital, Harvard Medical School, Boston, USA |
Publisher: |
Med Image Comput Comput Assist Interv. MICCAI 2006 |
Publication Date: |
Oct-2006 |
Volume Number: |
9 |
Issue Number: |
pt. 1 |
Pages: |
109-916 |
Citation: |
Int Conf Med Image Comput Comput Assist Interv. 2006;9(Pt 1):109-16. |
PubMed ID: |
17354880 |
Appears in Collections: |
NA-MIC, LMI, NAC, NCIGT, SLICER |
Sponsors: |
NIH P41 RR13218 NIH R01 MH50747 NIH P30 EY12196 NIH R21 MH67054 NIH U41 RR019703 NSF ITR 0426558 NIH Roadmap for Medical Research U54 EB005149 |
Generated Citation: |
Dauguet J., Peled S., Berezovskii V., Delzescaux T., Warfield S.K.., Born R., Westin C-F. 3D Histological Reconstruction of Fiber Tracts and Direct Comparison with Diffusion Tensor MRI Tractography. Int Conf Med Image Comput Comput Assist Interv. 2006;9(Pt 1):109-16. PMID: 17354880. |
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A classical neural tract tracer, WGA-HRP, was injected at multiple sites within the brain of a macaque monkey. Histological sections of the labeled fiber tracts were reconstructed in 3D, and the fibers were segmented and registered with the anatomical post-mortem MRI from the same animal. Fiber tracing along the same pathways was performed on the DTI data using a classical diffusion tracing technique. The fibers derived from the DTI were compared with those segmented from the histology in order to evaluate the performance of DTI fiber tracing. While there was generally good agreement between the two methods, our results reveal certain limitations of DTI tractography, particularly at regions of fiber tract crossing or bifurcation.
Additional Material
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Dauguet-MICCAI2006-fig5.jpg (278.051kB)