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Separation of Conjoined Twins with the Twin Reversed-arterial-perfusion Sequence after Prenatal Planning with Three-dimensional Modeling

Institution:
Department of Obstetrics, Gynecology, and Reproductive Biology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Publisher:
N Engl J Med
Publication Date:
Aug-2000
Volume Number:
343
Issue Number:
6
Pages:
399-402
Citation:
N Engl J Med. 2000 Aug 10;343(6):399-402.
PubMed ID:
10933739
Appears in Collections:
SPL, NCIGT, Prostate Group, SLICER
Generated Citation:
Norwitz E.R., Hoyte L., Jenkins K.J., van der Velde M.E., Ratiu P., Rodriguez-Thompson D., Wilkins-Haug L., Tempany C.M., Fishman S.J. Separation of Conjoined Twins with the Twin Reversed-arterial-perfusion Sequence after Prenatal Planning with Three-dimensional Modeling. N Engl J Med. 2000 Aug 10;343(6):399-402. PMID: 10933739.
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There are two congenital anomalies specific to multifetal pregnancies: twin reversed-arterial-perfusion sequence and conjoined twinning. The twin reversed-arterial-perfusion sequence is a rare complication of monozygous twinning in which one fetus (the "pump" twin) perfuses the other fetus (the "perfused" twin), resulting in reversed flow in the umbilical vessels and multiple structural anomalies, including acardia, in the perfused twin. (1) It occurs in fewer than 1 percent of pregnancies with monozygous twins and in about 1 in 35,000 births overall. (2, 3) Conjoined twinning occurs as a result of incomplete duplication of a single blastocyst during the process of monozygotic twinning. (4) It is a sporadic complication that occurs at rates ranging from 1 in 30,000 to 1 in 100,000 births.

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