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Future Potential of MRI-guided Focused Ultrasound Brain Surgery
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Institution: |
Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA. rrcolen@partners.org |
Publisher: |
Elsevier Science |
Publication Date: |
Aug-2010 |
Journal: |
Neuroimaging Clin N Am |
Volume Number: |
20 |
Issue Number: |
3 |
Pages: |
355-66 |
Citation: |
Neuroimaging Clin N Am. 2010 Aug;20(3):355-66. |
PubMed ID: |
20708551 |
Keywords: |
MRgFUS, Brain tumor, Focused ultrasound, Image-guided therapy |
Appears in Collections: |
NCIGT |
Generated Citation: |
Colen R.R., Jolesz F.A. Future Potential of MRI-guided Focused Ultrasound Brain Surgery. Neuroimaging Clin N Am. 2010 Aug;20(3):355-66. PMID: 20708551. |
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| Paper: | Download, View online |
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Magnetic resonance image-guided focused ultrasound surgery (MRgFUS) has surfaced as a viable noninvasive image-guided therapeutic method that integrates focused ultrasound (FUS), the therapeutic component, with magnetic resonance imaging (MRI), the image guidance module, into a real-time therapy delivery system with closed-loop control of energy delivery. The main applications for MRgFUS of the brain are thermal ablations for brain tumors and functional neurosurgery, and nonthermal, nonablative uses for disruption of the blood brain barrier (BBB) or blood clot and hematoma dissolution by liquification. The disruption of the BBB by FUS can be used for targeted delivery of chemotherapy and other therapeutic agents. MRI is used preoperatively for target definition and treatment planning, intraoperatively for procedure monitoring and control, and postoperatively for validating treatment success. Although challenges still remain, this integrated noninvasive therapy delivery system is anticipated to change current treatment paradigms in neurosurgery and the clinical neurosciences.
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