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Current Dipole Orientation and Distribution of Epileptiform Activity Correlates with Cortical Thinning in Left Mesiotemporal Epilepsy
Institution:
 1Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA 02129, USA.
2Department of Neurology, Ludwig Maximilians University, Josef-Schneider-Str. 11, 97078 Wuerzburg, Germany
3Department of Neurology, Brigham and Women's Hospital, 75 Francis St., Boston, MA 02115, USA
4Epilepsy Service, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA
5Division of Child Neurology, Ohio State University College of Medicine, Columbus, OH 43210, USA
6Department of Neurology, Children's Hospital Boston, 300 Longwood Avenue, Boston, MA 02115, USA
7Department of Neurosurgery and Radiology, Brigham and Women's Hospital, 75 Francis St., Boston, MA 02115, USA
8Department of Neurosurgery, Children's Hospital Boston, 300 Longwood Avenue, Boston, MA 02115, USA
Publisher:
 Elsevier Science
Publication Date:
 Oct-2010
Journal:
 Neuroimage
Volume Number:
 52
Issue Number:
 4
Pages:
 1238-42
Citation:
 Neuroimage. 2010 Oct 1;52(4):1238-42.
PubMed ID:
 20472073
PMCID:
 PMC3043985
Appears in Collections:
NCIGT
Sponsors:
 K08 MH067966 (MH) funded by NIMH NIH HHS
P01 CA067165 (CA) funded by NCI NIH HHS
P41 RR14075 (RR) funded by NCRR NIH HHS
R01 NS037462-07 (NS) funded by NINDS NIH HHS
P41 RR019703 (RR) funded by NCRR NIH HHS
Generated Citation:
 Reinsberger C., Tanaka N., Cole A.J., Lee J.W., Dworetzky B.A., Bromfield E.B., Hamiwka L., Bourgeois B.F., Golby A.J., Madsen J.R., Stufflebeam S.M. Current Dipole Orientation and Distribution of Epileptiform Activity Correlates with Cortical Thinning in Left Mesiotemporal Epilepsy. Neuroimage. 2010 Oct 1;52(4):1238-42. PMID: 20472073. PMCID: PMC3043985.
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To evaluate cortical architecture in mesial temporal lobe epilepsy (MTLE) with respect to electrophysiology, we analyze both magnetic resonance imaging (MRI) and magnetoencephalography (MEG) in 19 patients with left MTLE. We divide the patients into two groups: 9 patients (Group A) have vertically oriented antero-medial equivalent current dipoles (ECDs). 10 patients (Group B) have ECDs that are diversely oriented and widely distributed. Group analysis of MRI data shows widespread cortical thinning in Group B compared with Group A, in the left hemisphere involving the cingulate, supramarginal, occipitotemporal and parahippocampal gyri, precuneus and parietal lobule, and in the right hemisphere involving the fronto-medial, -central and -basal gyri and the precuneus. These results suggest that regardless of the presence of hippocampal sclerosis, in a subgroup of patients with MTLE a large cortical network is affected. This finding may, in part, explain the unfavorable outcome in some MTLE patients after epilepsy surgery.

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