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Evaluating the Validity of Volume-based and Surface-based Brain Image Registration for Developmental Cognitive Neuroscience Studies in Children 4 to 11 Years of Age
Institution:
 Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, MA, USA. satra@mit.edu
Publisher:
 Elsevier Science
Publication Date:
 Oct-2010
Journal:
 Neuroimage
Volume Number:
 53
Issue Number:
 1
Pages:
 85-93
Citation:
 Neuroimage. 2010 Oct 15;53(1):85-93.
PubMed ID:
 20621657
PMCID:
 PMC2914629
Appears in Collections:
NA-MIC
Sponsors:
 AG02238 (AG) funded by NIA NIH HHS
P41 RR1407 (RR) funded by NCRR NIH HHS
R01 NS052585-01 (NS) funded by NINDS NIH HHS
R01 EB006758 (EB) funded by NIBIB NIH HHS
R03 EB008673 (EB) funded by NIBIB NIH HHS
U54 EB005149 (EB) funded by NIBIB NIH HHS
Generated Citation:
 Ghosh S.S., Kakunoori S., Augustinack J., Nieto-Castanon A., Kovelman I., Gaab N., Christodoulou J.A., Triantafyllou C., Gabrieli J.D.E., Fischl B. Evaluating the Validity of Volume-based and Surface-based Brain Image Registration for Developmental Cognitive Neuroscience Studies in Children 4 to 11 Years of Age. Neuroimage. 2010 Oct 15;53(1):85-93. PMID: 20621657. PMCID: PMC2914629.
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Understanding the neurophysiology of human cognitive development relies on methods that enable accurate comparison of structural and functional neuroimaging data across brains from people of different ages. A fundamental question is whether the substantial brain growth and related changes in brain morphology that occur in early childhood permit valid comparisons of brain structure and function across ages. Here we investigated whether valid comparisons can be made in children from ages 4 to 11, and whether there are differences in the use of volume-based versus surface-based registration approaches for aligning structural landmarks across these ages. Regions corresponding to the calcarine sulcus, central sulcus, and Sylvian fissure in both the hemispheres were manually labeled on T1-weighted structural magnetic resonance images from 31 children ranging in age from 4.2 to 11.2years old. Quantitative measures of shape similarity and volumetric-overlap of these manually labeled regions were calculated when brains were aligned using a 12-parameter affine transform, SPM's nonlinear normalization, a diffeomorphic registration (ANTS), and FreeSurfer's surface-based registration. Registration error for normalization into a common reference framework across participants in this age range was lower than commonly used functional imaging resolutions. Surface-based registration provided significantly better alignment of cortical landmarks than volume-based registration. In addition, registering children's brains to a common space does not result in an age-associated bias between older and younger children, making it feasible to accurately compare structural properties and patterns of brain activation in children from ages 4 to 11.

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