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Towards Validation of DTI Tractography: Statistical Analysis of the Differences Observed Among Tractography Algorithms
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Pujol S.1, Magnotta V.2, De Siebenthal J.3, Kubicki M.3, Hayes K.1, Westin C-F.4, Lemaire J-J.5, Kikinis R.1, Gollub R.L.6, Wells III W.M.1
Institution: |
1Surgical Planning Laboratory, Department of Radiology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA. 2University of Iowa, Iowa City, IA, USA 3Psychiatry Neuroimaging Laboratory, Harvard Medical School, Boston, MA, USA 4Laboratory of Mathematics in Imaging, Harvard Medical School, Boston, MA, USA 5Department of Neurosurgery, Gabriel Montpied Hospital, Clermont-Ferrand, France 6Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA |
Publisher: |
Int Conf Med Image Comput Comput Assist Interv. MICCAI 2009 |
Publication Date: |
Sep-2009 |
Volume Number: |
11 |
Issue Number: |
WS |
Citation: |
Int Conf Med Image Comput Comput Assist Interv. 2009;12(WS). Workshop on Diffusion Modelling and the Fibre Cup. |
Keywords: |
DTI tractography, validation, statistical analysis |
Appears in Collections: |
NAC, LMI, NA-MIC, PNL, SPL |
Sponsors: |
NIH U54 EB005149 NIH P41 RR13218 |
Generated Citation: |
Pujol S., Magnotta V., De Siebenthal J., Kubicki M., Hayes K., Westin C-F., Lemaire J-J., Kikinis R., Gollub R.L., Wells III W.M. Towards Validation of DTI Tractography: Statistical Analysis of the Differences Observed Among Tractography Algorithms. Int Conf Med Image Comput Comput Assist Interv. 2009;12(WS). Workshop on Diffusion Modelling and the Fibre Cup. |
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| Paper: | Download, View online |
| Export citation: |
Validation of Diffusion Tensor Imaging (DTI) is challenging due to the absence of ground truth. Recent developments have demonstrated the feasibility of using the STAPLE algorithm to evaluate the performances of tractography methods. The goal of this paper is to present a workflow for assessing the sensitivity and specificity of deterministic and probabilistic tractography algorithms and to evaluate the statistical significance of the differences among tractography methods observed by STAPLE. We built a collection of 25 DTI replicates, and reconstructed the arcuate fasciculus using four tractography algorithms. Results showed statistically significant differences among the algorithms.
Additional Material
1 File (264.983kB)
Pujol-WS-MICAII2009-fig1.jpg (264.983kB)