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High Consistency of Regional Cortical Thinning in Aging Across Multiple Samples
Institution:
 Center for the Study of Human Cognition, Department of Psychology, University of Oslo, Olso 0317, Norway. andersmf@psykologi.uio.no
Publisher:
 Cereb Cortex
Publication Date:
 Sep-2009
Volume Number:
 19
Issue Number:
 9
Pages:
 2001-2012
Citation:
 Cereb Cortex. 2009 Sep;19(9):2001-12.
PubMed ID:
 19150922
PMCID:
 PMC2733683
Keywords:
 Aging, Cortex, Frontal lobes, Morphometry, MRI
Appears in Collections:
NA-MIC
Sponsors:
 P41 RR14075 (RR) funded by NCRR NIH HHS
R01 EB001550 (EB) funded by NIBIB NIH HHS
R01 NS052585-01 (NS) funded by NINDS NIH HHS
R01 RR16594-01A1 (RR) funded by NCRR NIH HHS
R01 NS39581 (NS) funded by NINDS NIH HHS
R01 RR13609 (RR) funded by NCRR NIH HHS
R01 EB006758 (EB) funded by NIBIB NIH HHS
R37 AG11230 (AG) funded by NIA NIH HHS
U24 RR021382 (RR) funded by NCRR NIH HHS
U54 EB005149 (EB) funded by NIBIB NIH HHS
Generated Citation:
 Fjell A.M., Westlye L.T., Amlien I., Espeseth T., Reinvang I., Raz N., Agartz I., Salat D.H., Greve D.N., Fischl B., Dale A.M., Walhovd K.B. High Consistency of Regional Cortical Thinning in Aging Across Multiple Samples. Cereb Cortex. 2009 Sep;19(9):2001-12. PMID: 19150922. PMCID: PMC2733683.
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Cross-sectional magnetic resonance imaging (MRI) studies of cortical thickness and volume have shown age effects on large areas, but there are substantial discrepancies across studies regarding the localization and magnitude of effects. These discrepancies hinder understanding of effects of aging on brain morphometry, and limit the potential usefulness of MR in research on healthy and pathological age-related brain changes. The present study was undertaken to overcome this problem by assessing the consistency of age effects on cortical thickness across 6 different samples with a total of 883 participants. A surface-based segmentation procedure (FreeSurfer) was used to calculate cortical thickness continuously across the brain surface. The results showed consistent age effects across samples in the superior, middle, and inferior frontal gyri, superior and middle temporal gyri, precuneus, inferior and superior parietal cortices, fusiform and lingual gyri, and the temporo-parietal junction. The strongest effects were seen in the superior and inferior frontal gyri, as well as superior parts of the temporal lobe. The inferior temporal lobe and anterior cingulate cortices were relatively less affected by age. The results are discussed in relation to leading theories of cognitive aging.

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