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Minute Effects of Sex on the Aging Brain: A Multisample Magnetic Resonance Imaging Study of Healthy Aging and Alzheimer's Disease
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Fjell A.M., Westlye L.T., Amlien I., Espeseth T., Reinvang I., Raz N., Agartz I., Salat D.H., Greve D.N., Fischl B., Dale A.M., Walhovd K.B.
Institution: |
Center for the Study of Human Cognition, Department of Psychology, University of Oslo, 0317 Oslo, Norway. |
Publisher: |
HighWire Press |
Publication Date: |
Jul-2009 |
Journal: |
J Neurosci |
Volume Number: |
29 |
Issue Number: |
27 |
Pages: |
8774-83 |
Citation: |
J Neurosci. 2009 Jul 8;29(27):8774-83. |
PubMed ID: |
19587284 |
PMCID: |
PMC2782778 |
Keywords: |
MRI, aging, sex, cerebral cortex, hippocampus, FreeSurfer |
Appears in Collections: |
NA-MIC |
Sponsors: |
P01 AG03991 (AG) funded by NIA NIH HHS P20 MH071616 (MH) funded by NIMH NIH HHS P41 RR14075 (RR) funded by NCRR NIH HHS P50 AG05681 (AG) funded by NIA NIH HHS R01 EB001550 (EB) funded by NIBIB NIH HHS R01 NS052585-01 (NS) funded by NINDS NIH HHS R01 RR16594-01A1 (RR) funded by NCRR NIH HHS R01 NS39581 (NS) funded by NINDS NIH HHS R01 RR13609 (RR) funded by NCRR NIH HHS R01 EB006758 (EB) funded by NIBIB NIH HHS R37 AG11230 (AG) funded by NIA NIH HHS RR 16594 (RR) funded by NCRR NIH HHS RR14075 (RR) funded by NCRR NIH HHS U24 RR021382 (RR) funded by NCRR NIH HHS U54 EB005149 (EB) funded by NIBIB NIH HHS |
Generated Citation: |
Fjell A.M., Westlye L.T., Amlien I., Espeseth T., Reinvang I., Raz N., Agartz I., Salat D.H., Greve D.N., Fischl B., Dale A.M., Walhovd K.B. Minute Effects of Sex on the Aging Brain: A Multisample Magnetic Resonance Imaging Study of Healthy Aging and Alzheimer's Disease. J Neurosci. 2009 Jul 8;29(27):8774-83. PMID: 19587284. PMCID: PMC2782778. |
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Age is associated with substantial macrostructural brain changes. While some recent magnetic resonance imaging studies have reported larger age effects in men than women, others find no sex differences. As brain morphometry is a potentially important tool in diagnosis and monitoring of age-related neurological diseases, e.g., Alzheimer's disease (AD), it is important to know whether sex influences brain aging. We analyzed cross-sectional magnetic resonance scans from 1143 healthy participants from seven subsamples provided by four independent research groups. In addition, 96 patients with mild AD were included. Estimates of cortical thickness continuously across the brain surface, as well as volume of 17 subcortical structures, were obtained by use of automated segmentation tools (FreeSurfer). In the healthy participants, no differences in aging slopes between women and men were found in any part of the cortex. Pallidum corrected for intracranial volume showed slightly higher age correlations for men. The analyses were repeated in each of the seven subsamples, and the lack of age x sex interactions was largely replicated. Analyses of the AD sample showed no interactions between sex and age for any brain region. We conclude that sex has negligible effects on the age slope of brain volumes both in healthy participants and in AD.
Additional Material
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