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Carr-Purcell-Meiboom-Gill (CPMG) Imaging of Prostate Cancer: Quantitative T₂ Values for Cancer Discrimination

Institution:	Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Publisher:	Magn Reson Imaging
Publication Date:	May-2009
Volume Number:	27
Issue Number:	4
Pages:	497-502
Citation:	Magn Reson Imaging. 2009 May;27(4):497-502.
PubMed ID:	18823731
PMCID:	PMC2720831
Appears in Collections:	Prostate Group, NCIGT
Sponsors:	5R01 CA109246-02 (CA) funded by NCI NIH HHS 5R25 CA089017 (CA) funded by NCI NIH HHS U41 RR019703 (RR) funded by NCRR NIH HHS
Generated Citation:	Roebuck J.R., Haker S.J., Mitsouras D., Rybicki F.J., Tempany C.M., Mulkern R.V. Carr-Purcell-Meiboom-Gill (CPMG) Imaging of Prostate Cancer: Quantitative T2 Values for Cancer Discrimination. Magn Reson Imaging. 2009 May;27(4):497-502. PMID: 18823731. PMCID: PMC2720831.
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Quantitative, apparent T(2) values of suspected prostate cancer and healthy peripheral zone tissue in men with prostate cancer were measured using a Carr-Purcell-Meiboom-Gill (CPMG) imaging sequence in order to assess the cancer discrimination potential of tissue T(2) values. The CPMG imaging sequence was used to image the prostates of 18 men with biopsy-proven prostate cancer. Whole gland coverage with nominal voxel volumes of 0.54 x 1.1 x 4 mm³ was obtained in 10.7 min, resulting in data sets suitable for generating high-quality images with variable T(2)-weighting and for evaluating quantitative T(2) values on a pixel-by-pixel basis. Region-of-interest analysis of suspected healthy peripheral zone tissue and suspected cancer, identified on the basis of both T(1)- and T(2)-weighted signal intensities and available histopathology reports, yielded significantly (P<.0001) longer apparent T(2) values in suspected healthy tissue (193±49 ms) vs. suspected cancer (100±26 ms), suggesting potential utility of this method as a tissue specific discrimination index for prostate cancer. We conclude that CPMG imaging of the prostate can be performed in reasonable scan times and can provide advantages over T(2)-weighted fast spin echo (FSE) imaging alone, including quantitative T(2) values for cancer discrimination as well as proton density maps without the point spread function degradation associated with short effective echo time FSE sequences.

Roebuck-MRI2009-fig2.jpg (120.056kB)