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An MRI Study of Age-related White and Gray Matter Volume Changes in the Rhesus Monkey
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Institution: |
1Laboratory for Cognitive Neurobiology, Department of Anatomy and Neurobiology, Boston University School of Medicine, Boston, MA 02118, USA. jjwisco@mednet.ucla.edu 2Center for Neurological Imaging, Department of Radiology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA. 3Computational Radiology Laboratory, Departments of Radiology, Children’s Hospital and Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA 4Yerkes National Primate Research Center, Emory University, Atlanta, GA 30322, USA. |
Publisher: |
Neurobiol Aging |
Publication Date: |
Oct-2008 |
Volume Number: |
29 |
Issue Number: |
10 |
Pages: |
1563-1575 |
Citation: |
Neurobiol Aging. 2008 Oct;29(10):1563-75. |
PubMed ID: |
17459528 |
PMCID: |
PMC2605721 |
Keywords: |
Rhesus monkey, MRI, Gray matter, White matter, Template Driven Segmentation (TDS), Cerebral cortex |
Appears in Collections: |
CNI, CRL, NAC, SLICER |
Sponsors: |
F31 AG05897 (AG) funded by United States NIA P01 AG00001 (AG) funded by United States NIA P41 RR13218-01 (RR) funded by United States NCRR P51 RR00165 (RR) funded by United States NCRR R01 NS35142 (NS) funded by United States NINDS R21 MH067054 (MH) funded by United States NIMH R37 AG17609 (AG) funded by United States NIA |
Generated Citation: |
Wisco J.J., Killiany R.J., Guttmann C.R.G., Warfield S.K., Moss M.B., Rosene D.L. An MRI Study of Age-related White and Gray Matter Volume Changes in the Rhesus Monkey. Neurobiol Aging. 2008 Oct;29(10):1563-75. PMID: 17459528. PMCID: PMC2605721. |
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We applied the automated MRI segmentation technique Template Driven Segmentation (TDS) to dual-echo spin echo (DE SE) images of eight young (5-12 years), six middle-aged (16-19 years) and eight old (24-30 years) rhesus monkeys. We analyzed standardized mean volumes for 18 anatomically defined regions of interest (ROI's) and found an overall decrease from young to old age in the total forebrain (5.01%), forebrain parenchyma (5.24%), forebrain white matter (11.53%), forebrain gray matter (2.08%), caudate nucleus (11.79%) and globus pallidus (18.26%). Corresponding behavioral data for five of the young, five of the middle-aged and seven of the old subjects on the Delayed Non-matching to Sample (DNMS) task, the Delayed-recognition Span Task (DRST) and the Cognitive Impairment Index (CII) were also analyzed. We found that none of the cognitive measures were related to ROI volume changes in our sample size of monkeys.
Additional Material
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Wisco-NeurobiolAging2008-fig1.jpg (295.386kB)