The Publication Database hosted by SPL

All Publications | Upload | Advanced Search | Gallery View | Download Statistics | Help | Import | Log in

Reproducibility of Functional MR Imaging: Preliminary Results of Prospective Multi-institutional Study Performed by Biomedical Informatics Research Network
Institution:
 Surgical Planning Laboratory, Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Publisher:
 Radiology
Publication Date:
 Dec-2005
Volume Number:
 237
Issue Number:
 3
Pages:
 781-789
Citation:
 Radiology. 2005 Dec;237(3):781-9.
PubMed ID:
 16304101
PMCID:
 PMC1351264
Appears in Collections:
NAC, CRL, SLICER, SPL
Sponsors:
 NCRR P41 RR13218
NCRR P41 RR14075
NLM R01 LM007861-03
NLM R01 LM007861-01
AHCPR R03 HS013234-01
NCI R21 CA89449-01
R21MH67054 (MH) funded by NIMH
Generated Citation:
 Zou K.H., Greve D.N., Wang M., Pieper S.D., Warfield S.K., White N.S., Manandhar S., Brown G.G., Vangel M.G., Kikinis R., Wells III W.M. Reproducibility of Functional MR Imaging: Preliminary Results of Prospective Multi-institutional Study Performed by Biomedical Informatics Research Network. Radiology. 2005 Dec;237(3):781-9. PMID: 16304101. PMCID: PMC1351264.
Downloaded: 810 times. [view map]
Paper: Download, View online
Export citation:

To prospectively investigate the factors--including subject, brain hemisphere, study site, field strength, imaging unit vendor, imaging run, and examination visit--affecting the reproducibility of functional magnetic resonance (MR) imaging activations based on a repeated sensory-motor (SM) task. MATERIALS AND METHODS: The institutional review boards of all participating sites approved this HIPAA-compliant study. All subjects gave informed consent. Functional MR imaging data were repeatedly acquired from five healthy men aged 20-29 years who performed the same SM task at 10 sites. Five 1.5-T MR imaging units, four 3.0-T units, and one 4.0-T unit were used. The subjects performed bilateral finger tapping on button boxes with a 3-Hz audio cue and a reversing checkerboard. In a block design, 15-second epochs of alternating baseline and tasks yielded 85 acquisitions per run. Functional MR images were acquired with block-design echo-planar or spiral gradient-echo sequences. Brain activation maps standardized in a unit-sphere for the left and right hemispheres of each subject were constructed. Areas under the receiver operating characteristic curve, intraclass correlation coefficients, multiple regression analysis, and paired Student t tests were used for statistical analyses.

Additional Material
1 File (123.155kB)
Zou-fBIRN-Radiology2005-fig1.jpg (123.155kB)