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Intrauterine Growth Restriction Affects the Preterm Infant's Hippocampus
Institution:
 1Department of Pediatrics, Washington University, St Louis, Missouri 63110, USA. lodygensky_g@kids.wustl.edu
2Computational Radiology Laboratory, Departments of Radiology, Children’s Hospital and Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA.
3Child Development Unit, Department of Paediatrics, School of Medicine, University of Geneva, Switzerland.
Publisher:
 Pediatr Res
Publication Date:
 Apr-2008
Volume Number:
 63
Issue Number:
 4
Pages:
 438-443
Citation:
 Pediatr Res. 2008 Apr;63(4):438-43.
PubMed ID:
 18356754
Appears in Collections:
CRL, NAC, SLICER
Sponsors:
 P41 RR13218 (RR) funded by United States NCRR
R01 RR021885 (RR) funded by United States NCRR
R03 CA126466 (CA) funded by United States NCI
Generated Citation:
 Lodygensky G.A., Seghier M.L., Warfield S.K., Tolsa C.B., Sizonenko S., Lazeyras F., Huppi P.S. Intrauterine Growth Restriction Affects the Preterm Infant's Hippocampus. Pediatr Res. 2008 Apr;63(4):438-43. PMID: 18356754.
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The hippocampus is known to be vulnerable to hypoxia, stress, and undernutrition, all likely to be present in fetal intrauterine growth restriction (IUGR). The effect of IUGR in preterm infants on the hippocampus was studied using 3D magnetic resonance imaging at term-equivalent age Thirteen preterm infants born with IUGR after placental insufficiency were compared with 13 infants with normal intrauterine growth age matched for gestational age. The hippocampal structural differences were defined using voxel-based morphometry and manual segmentation. The specific neurobehavioral function was evaluated by the Assessment of Preterm Infants' Behavior at term and at 24 mo of corrected age by a Bayley Scales of Infant and Toddler Development. Voxel-based morphometry detected significant gray matter volume differences in the hippocampus between the two groups. This finding was confirmed by manual segmentation of the hippocampus with a reduction of hippocampal volume after IUGR. The hippocampal volume reduction was further associated with functional behavioral differences at term-equivalent age in all six subdomains of the Assessment of Preterm Infants' Behavior but not at 24 mo of corrected age. We conclude that hippocampal development in IUGR is altered and might result from a combination of maternal corticosteroid hormone exposure, hypoxemia, and micronutrient deficiency.

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